Pathology & Specimen Processing
Pathology & Specimen Processing
Penn State College of Medicine offers a variety of services in pathology and specimen processing, including the Clinical Research Biospecimen Core, opened in 2016.
Other resources include a biorepository and tissue bank co-managed between the Institute for Personalized Medicine and the Cancer Institute, as well as human and animal pathology expertise.
- Clinical Research Biospecimen Core
- Molecular and Histopathology Core
- Pathology Core Reference Lab
- Other Services
Clinical Research Biospecimen Core
The mission of Penn State College of Medicine's Clinical Research Biospecimen Core is to provide a centralized service for the processing and distribution of human subject research samples for all clinical research activities at the College of Medicine and Penn State Health Milton S. Hershey Medical Center.
(internal users only)
The Clinical Research Biospecimen Core will perform all of the basic activities necessary to process and ship clinical research specimens for Penn State College of Medicine investigators.
Sample processing services will include separation, extraction and short-term storage (refrigeration and/or freezing) of the samples prior to distribution. Services and expertise will be available to provide complex processing as well.
This core also serves as a central location for all researchers to ship samples to outside central laboratories for extramurally sponsored trials and investigator-sponsored research.
Penn State College of Medicine's Clinical Research Biospecimen Core has two goals:
- First, by providing a centralized core service dedicated solely to this purpose, the core will help internal Penn State investigators to more effectively and efficiently conduct their human subject research efforts, and to budget for such efforts.
- Additionally, by providing a centralized service for clinical research sample handling, the core seeks to attract more external collaborators and extramural research sponsors thanks to more favorable study contract pricing.
Molecular and Histopathology Core
The Molecular and Histopathology Core, part of the Department of Pathology and Laboratory Medicine, provides a broad array of state-of-the-art technical and professional pathology-related services critical to biomedical investigations conducted at Penn State College of Medicine and Penn State Health Milton S. Hershey Medical Center.
- Routine Histology (processing, embedding, sectioning and hematoxylin and eosin staining)
- Histochemical Stains
- Immunohistochemical Stains
- In Situ Hybridization
- Tissue Microarray
- Laser Capture Microdissection (LCM)
- Archival FFPE Human Tissue Samples
Pathology Core Reference Laboratory
The Pathology Core Reference Laboratory at Penn State College of Medicine is a CLIA-certified, fully-accredited reference laboratory that specializes in the quantitative analysis of hormones, hormone receptors, cytokines and growth factors in blood, urine, tissues and culture medium from both human subjects and experimental animals.
The Pathology Core Reference Laboratory provides support for both clinical diagnostic testing as well as for clinical research studies at Penn State Health Milton S. Hershey Medical Center. In addition, the lab extends its testing support to a number of clinical investigators at other universities, including the University of Connecticut Health Sciences Center, Ohio State University Clinical Research Center and the Population Council at Rockefeller University in New York.
The lab also carries out an educational mission through its weekly conferences, at which test results are reviewed and discussed with medical house staff, residents and medical students.
The Pathology Core Reference Laboratory's extramural support also includes contracts with pharmaceutical houses and diagnostic companies to support clinical drug trials and evaluations of reagents and instruments.
Penn State College of Medicine offers a variety of other pathology and specimen-processing services to internal and external investigators.
Cell Line Authentication
As part of the National Institutes of Health’s focus on Increasing Rigor and Reproducibility in Research, a description of cell line authentication methods to be used is now required in all NIH grant applications.
(internal users only)
While any cell line authentication service or valid internal method can be used for this purpose, the Penn State College of Medicine Research Team secured discounted rates for Penn State University researchers from any campus for human cell line authentication with Genetica, a commercial company.
Complete information about how to submit cell-line samples to Genetica is available to Penn State College of Medicine investigators on the College Infonet (internal access only).
Investigators at other Penn State campuses who wish to use this service can access forms and guidelines in this Box folder by logging in with their PSU Access ID.
Penn State College of Medicine's Department of Comparative Medicine offers a Comparative Pathology Service to provide researchers access to experts in veterinary and comparative pathology.
Services available include gross necropsy, histopathology (including semi-quantitative or quantitative analysis), immunohistochemistry, phenotyping, development/implementation of analysis techniques, manuscript review, and clinical pathology.
For details on the comparative pathology service, email Nannette Kirst in the Department of Comparative Medicine at firstname.lastname@example.org.