Microbiology & Immunology at Penn State College of Medicine
The mission of the Department of Microbiology & Immunology is to make high-impact, cutting-edge discoveries that help conquer human disease and answer many of the major scientific questions confronting molecular and cellular biologists.
The outstanding faculty of the Microbiology & Immunology Department are known for their major contributions in molecular and structural virology, viral pathogenesis, and viral and tumor immunology. Members of the faculty have attained national and international recognition for their research endeavors, as evidenced by their outstanding record of scientific publications, membership and leadership roles on national scientific review committees and advisory panels, appointments on editorial boards of leading virology and immunology journals, and strong extramural grant funding.
Our graduates have been highly successful in obtaining postdoctoral positions in leading laboratories at major research centers and establishing rewarding careers as scientific investigators and educators.
Studies of microorganisms and their interactions with host cells, as well as the immune system, are generating knowledge used to conquer human disease and also providing answers to many of the major scientific questions confronting molecular and cellular biologists. Virology, immunology, oncology, and metabolic diseases are broad research areas being pursued by various members of the department, with research opportunities available to explore interactions of viruses with host cells and organisms, virus replication and assembly, viral latency and reactivation, and innate and adaptive immune responses in host defense, autoimmunity, and mucosal immunity and inflammation.
Aron Lukacher, MD, PhD
Microbiology & Immunology Department Chair
Penn State College of Medicine
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Latest from Microbiology & Immunology
- The rabbit papillomavirus model: a valuable tool to study viral-host interactions.Cladel NM, Peng X, Christensen N, Hu J. Philos Trans R Soc Lond B Biol Sci 2019 May 27;374(1773):20180294
- Differential requirements for gE, gI, and UL16 among HSV-1 syncytial variants suggest unique modes of dysregulating the mechanism of cell-to-cell spread.Carmichael JC, Wills JW. J Virol 2019 May 15. pii: JVI.00494-19 [Epub ahead of print]
- Parvovirus B19 Uncoating Occurs in the Cytoplasm without Capsid Disassembly and It Is Facilitated by Depletion of Capsid-Associated Divalent Cations.Caliaro O, Marti A, Ruprecht N, Leisi R, Subramanian S, Hafenstein S, Ros C. Viruses 2019 May 10;11(5). pii: E430
- Viral engagement with host (co-)receptors blocked by a novel class of tryptophan dendrimers that targets the 5-fold-axis of the enterovirus-A71 capsid.Sun L, Lee H, Thibaut HJ, Lanko K, Rivero-Buceta E, Bator C, Martinez-Gualda B, Dallmeier K, Delang L, Leyssen P, Gago F, San-Félix A, Hafenstein S, Mirabelli C, Neyts J. PLoS Pathog 2019 May 9;15(5):e1007760 [Epub ahead of print]