George-Lucian Moldovan, PhD

Our vision is to provide novel drug targets for cancer prevention and personalized cancer treatment. To achieve this long-term goal, our laboratory employs a combination of cellular, molecular, genetic, genome editing, and functional genomics methods. Our research program encompasses three strategic themes: 1) To understand the molecular machineries involved in maintaining genomic integrity during DNA replication; 2) To uncover novel mechanisms of repair of DNA damage induced by radiation, chemotherapy, and environmental agents and understand how they contribute to genomic instability and therapy resistance; 3) To infer the impact of individual tumor genetic make-up on the response to cancer therapy.